Definition

A cutaneous T-cell lymphoma with leukemic dissemination of mutated T cells

Epidemiology

advanced form of mycosis fungoides or arise de novo

Clinical features

• Systemic skin lesions
  • Erythroderma accompanied by palmar and plantar hyperkeratosis
  • Intense pruritus
• Generalized lymphadenopathy

Diagnostics

Atypical T cells (Sézary cells) on peripheral blood smear